Semaglutide and tirzepatide are peptides. So are CJC-1295, Sermorelin, and Tesamorelin. Here is how they compare — and which providers offer them through licensed physicians.
Ozempic, Wegovy, Zepbound, and Mounjaro are all peptides — synthetic versions of naturally occurring gut hormones. The peptides on this page work through different mechanisms but share the same goal: helping your body regulate metabolism, reduce fat, and support weight loss. GLP-1s have the strongest clinical evidence. Other peptides are increasingly popular as adjuncts or alternatives.
The most clinically validated weight loss peptides available. FDA-approved, widely available through telehealth, and the strongest evidence base of any weight loss medication in history.
Semaglutide is a GLP-1 receptor agonist — a synthetic version of a naturally occurring gut hormone that signals fullness to the brain, slows digestion, and improves insulin sensitivity. At the 2.4mg weekly dose used in Wegovy, it produces an average of 15% body weight loss over 68 weeks. The December 2025 FDA approval of the Wegovy pill (oral semaglutide 25mg) made it the first oral GLP-1 approved for weight loss, producing approximately 17% average weight loss in clinical trials.
Tirzepatide is a dual GIP and GLP-1 receptor agonist — it activates two metabolic hormones simultaneously, making it the most effective weight loss medication currently available. Clinical trials show an average of 21% body weight loss over 72 weeks at the highest dose. For context, that is more than twice the weight loss seen with older anti-obesity medications. Available as Zepbound for weight loss and Mounjaro for diabetes.
These peptides stimulate your body's own growth hormone production — which naturally declines after age 30. Higher GH levels accelerate fat metabolism, improve body composition, and support lean muscle. Often stacked with GLP-1s for enhanced results.
CJC-1295 and Ipamorelin work as a team — CJC-1295 provides sustained growth hormone release over days while Ipamorelin delivers immediate GH pulses without raising cortisol. Together they create a complementary GH release pattern that mimics your body's natural rhythm. Most users notice improved sleep within 2 to 4 weeks, with body composition changes visible at 6 to 8 weeks. Widely used alongside GLP-1 therapy for enhanced fat loss.
Sermorelin has the longest clinical track record of any GH releasing peptide — it was previously FDA-approved as Geref for treating GH deficiency in children, giving it a stronger regulatory history than newer peptides. It stimulates the pituitary gland to release natural growth hormone, supporting fat loss, lean muscle, improved sleep, and anti-aging effects. Pricing ranges from $175 to $225 per month through reputable telehealth providers.
Tesamorelin is the most clinically potent GH releasing peptide available and the only one with an FDA approval — it is approved as Egrifta for HIV-associated lipodystrophy (abnormal abdominal fat accumulation). Multiple studies show significant reductions in visceral adipose tissue — the dangerous fat stored around internal organs. For patients with significant abdominal fat despite GLP-1 therapy, Tesamorelin may be a powerful addition.
For patients who cannot tolerate GLP-1s or want additional fat-targeting support. These peptides work through different mechanisms — targeting fat metabolism directly rather than appetite.
AOD-9604 is derived from a specific fragment of the human growth hormone molecule associated with fat metabolism. Unlike GLP-1s which work primarily through appetite suppression, AOD-9604 targets fat directly — stimulating lipolysis (fat breakdown) and inhibiting lipogenesis (new fat creation) without significantly affecting blood sugar or insulin. This makes it a potential option for patients who want fat loss support without GLP-1 side effects.
| Peptide | Avg Weight Loss | FDA Status | Starting Cost | Via Telehealth | Stack with GLP-1 |
|---|---|---|---|---|---|
| Tirzepatide (Zepbound) | ~21% | ✓ Approved | $166/mo compounded | ✓ Yes | N/A — is a GLP-1 |
| Semaglutide (Wegovy) | ~15–17% | ✓ Approved | $99/mo compounded | ✓ Yes | N/A — is a GLP-1 |
| Tesamorelin | Visceral fat focus | ✓ Approved (Egrifta) | $200+/mo | ✓ Yes | ✓ Excellent |
| CJC-1295 + Ipamorelin | Body recomposition | ✗ Off-label | $150+/mo | ✓ Yes | ✓ Popular stack |
| Sermorelin | Body recomposition | ✗ Off-label | $175/mo | ✓ Yes | ✓ Yes |
| AOD-9604 | Mild fat reduction | ✗ Research compound | Varies | ✓ Limited | ✓ Yes |
GLP-1 medications (semaglutide and tirzepatide) have robust FDA approval and extensive clinical trial data. Other peptides on this page are prescribed off-label through licensed compounding pharmacies. They are legal when prescribed by a licensed physician but have not received FDA approval for weight loss. Always consult a licensed healthcare provider before starting any peptide therapy. This page is for informational purposes only.
These telehealth platforms offer both GLP-1 medications and additional peptide therapy through licensed physicians. All require a medical consultation before prescribing.
Peter MD offers GLP-1 medications alongside hormone optimization and peptide therapy including Sermorelin and CJC-1295/Ipamorelin. 13,985 Trustpilot reviews. Price match guarantee. One of the few platforms where you can access GLP-1 therapy and peptide therapy through the same provider.
Get Thin MD offers one of the most comprehensive menus of peptide and hormone therapies alongside GLP-1 medications — including Sermorelin, NAD+, hair loss support, and anti-aging solutions. Available in all 50 states. All-in pricing with no hidden fees.
Willow offers compounded semaglutide and tirzepatide through licensed physicians, with both injectable and oral sublingual tablet options. Same-day prescriptions, free shipping, and unlimited physician access. One of the few platforms offering an oral alternative for needle-averse patients.
Hers (the women's brand of Hims & Hers) offers compounded semaglutide starting at $199/mo as well as brand-name Wegovy, Ozempic, Zepbound, and Mounjaro. One of the few platforms offering both compounded and FDA-approved options. FSA/HSA eligible. Prepaid plans available.
Ivim Health offers some of the lowest compounded GLP-1 prices available — semaglutide from $75/mo and tirzepatide from $133/mo — with a weekly individualized dosing model and weekly provider check-ins. Published peer-reviewed clinical data showing 19.5% average weight loss. Available in 49 states.
Henry Meds offers compounded semaglutide and tirzepatide in multiple formats — weekly injections, daily oral tablets, and sublingual drops — with all-inclusive flat monthly pricing that covers medication, supplies, shipping, and provider visits. 4.5 stars across 12,000+ Trustpilot reviews.
The following suppliers sell research-grade peptides for laboratory and scientific research purposes only. Products are not intended for human use. We recommend working with a licensed telehealth provider for physician-supervised peptide therapy — but for those researching independently, these are well-regarded suppliers in the research community.
All products from these suppliers are sold strictly for laboratory research purposes and are not approved for human consumption. They are not medications, supplements, or treatments. Always consult a licensed healthcare provider before using any compound. By visiting these suppliers you confirm you are 21+ and understand products are for research use only.
One of the most competitively priced research peptide suppliers in the market. Known for fast same-day shipping, purity certificates on every product, and strong customer service. Widely recommended across the peptide research community. US shipping only.
Sister brand to Atomik Labz offering a complementary catalog of research peptides. Frequently runs joint promotions including BOGO deals and sitewide discounts. Carries several compounds not available at Atomik Labz including CJC-1295, Ipamorelin, KPV, and AOD-9604 — key weight loss peptides. Same commitment to quality and fast fulfillment.
Use our free comparison tool to find the most affordable GLP-1 provider for your situation — many also offer peptide therapy.